Graph-Enriched Biomedical Entity Representation Transformer

Аннотация

Infusing external domain-specific knowledge about diverse biomedical concepts and relationships into language models (LMs) advances their ability to handle specialised in-domain tasks like medical concept normalization (MCN). However, existing biomedical LMs are primarily trained with contrastive learning using synonymous concept names from a terminology (e.g., UMLS) as positive anchors, while accurate aggregation of the features of graph nodes and neighbors remains a challenge. In this paper, we present Graph-Enriched Biomedical Entity Representation Transformer (GEBERT) which captures graph structural data from the UMLS via graph neural networks and contrastive learning. In GEBERT, we enrich the entity representations by introducing an additional graph-based node-level contrastive objective. To enable mutual knowledge sharing among the textual and the structural modalities, we minimize the contrastive objective between a concept’s node representation and its textual embedding obtained via LM. We explore several state-of-the-art convolutional graph architectures, namely GraphSAGE and GAT, to learn relational information from local node neighborhood. After task-specific supervision, GEBERT achieves state-of-the-art results on five MCN datasets in English.