Prevalence of COVID-19-associated pneumonia signs on chest computed tomography in cancer patients: the ARILUS study

Abstract

Aim. To study the prevalence of pneumonia features associated with 2019 coronavirus disease (COVID-19) in cancer patients based on chest computed tomography (CT) data using an artificial intelligence (AI) algorithm.Materials and methods. A cross-sectional study was conducted as part of the ARILUS project. Using multitarget AI, CT images of 1148 patients examined at the Arkhangelsk Clinical Oncology Dispensary from 01.04. 2020 to 31.12. 2021 were analyzed. Patients were divided into groups: without signs of pneumonia (n= 592, 51.6%) and with signs of pneumonia (n= 556, 48.4%). In 95.3% of patients with pneumonia, the lesion volume was less than 25%(CT-1). Using multivariate Poisson regression, adjusted prevalence ratios (aPR) with 95% confidence intervals (CI) were calculated.Results. For demographic characteristics such as gender, age, place of residence, no relationship with the presence of signs of COVID-19 pneumonia was established. Topography of neoplasm is associated with the presence of signs of COVID-19 pneumonia (reference group–cancers of the female genital organs): lung cancer–aPR 1.87; 95% CI: 1.40–2.49; head and neck cancers–aPR 1.85; 95% CI: 1.32–2.58; upper gastrointestinal tract–aPR 1.51; 95% CI: 1.12–2.04; breast cancer–aPR: 1.38; 95% CI: 1.00–1.90; p< 0.01. The presence of pulmonary emphysema is associated with signs of COVID-19 pneumonia: aPR 1.25; 95% CI: 1.09–1.45, p= 0.002. With an increase in the Agatston score (AS) reflecting coronary artery calcification (reference group absence of calcification), the association with the presence of signs of COVID-19 pneumonia …